cellulitis from moderna covid vaccine cellulitis from moderna covid vaccine

The Pfizer subgroup represented a smaller sample size (34 first-dose reports and 40 second-dose reports), but the pattern of skin reactions was similar to that observed with the Moderna vaccine. The .gov means its official. Chest imaging (ie, x-ray or CT), urinalysis, and a search for stool blood were also negative. UK cements 10-year-partnership with Moderna in major boost for vaccines Spikevax will be given to you as two 0.5 mL injections. The clinical features of the patients are summarised in the, All cases were investigated for laboratory abnormalities or organ involvements that are typically associated with small-vessel vasculitis. Disclaimer. The vaccine was also effective in people aged 65 years and in adolescents aged 12 to 17 years. Information about both vaccine doses was available for 180 patients, 29 of whom had skin reactions after both doses. Cellulitis | Johns Hopkins Medicine 2006;1172-1191. The use of the eHealthMe site and its content is at your own risk. Health Minister Greg Hunt's infection is revealed after Covid jab Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Monts, France 37260, Moderna Biotech Spain S.L. doi:10.1056/NEJMoa2035389, Robinson LB, Fu X, Hashimoto D, et al. You may need to read it again. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. THURSDAY, March 4, 2021 (HealthDay News) -- Some people given the Moderna COVID-19 vaccine may develop a reaction at the injection site that can first appear . In addition, your close contacts Bookshelf National Library of Medicine SARS-CoV-2 infection has resulted in more than 4 million deaths worldwide, often due to excessive or aberrant host immune responses. PMC feeling faint or light-headed changes in your heartbeat shortness of breath wheezing swelling of your lips, face, tongue or throat hives or rash nausea or vomiting stomach pain Talk to your doctor. T cells are a part of the immune system that directly attacks threats and help protect you from infections. COVID Arm: Delayed Hypersensitivity Reactions to SARS-CoV-2 Vaccines Misdiagnosed as Cellulitis. She has previously written for publications including Insider and Cancer Health. COVID-19: Allergic reactions to SARS-CoV-2 vaccines - UpToDate To update your cookie settings, please visit the, https://doi.org/10.1016/S2665-9913(21)00309-X, Cutaneous vasculitis following COVID-19 vaccination, https://www.governo.it/it/cscovid19/report-vaccini, View Large Spain, Rovi Pharma Industrial Services, S.A. Verywell Health's content is for informational and educational purposes only. The site is secure. COVID-19 vaccine-induced cellulitis and myositis Local injection-site reactions occurred in 54% of patients after the first Moderna dose and 70% after the second dose. Ankylosing Spondylitis and the COVID Vaccine: Is It Safe? The preferred site is the deltoid muscle of the upper arm. 2020 Dec 1;16(12):2891-2904. doi: 10.1080/21645515.2020.1788310. The initial report was limited to skin reactions associated with the Moderna and Pfizer vaccines, the only two with EUAs at the time of data analysis. . Published 2021. Eczema and the COVID-19 Vaccine: Is it Safe? Moderna's COVID-19 vaccine, also known as mRNA-1273, is a two-dose vaccine. They also stress that concerns about a skin reaction should not keep people from getting vaccinated. She has previously written for publications including Insider and Cancer Health. The content on this site is intended for healthcare professionals. You have rejected additional cookies. We study millions of patients and 5,000 more each day. Dont worry we wont send you spam or share your email address with anyone. While experiencing a reaction to a new vaccine can be frightening, Moderna only "reported delayed skin reactions in its large clinical trial in 0.8 percent of recipients after the first dose,. Lipid SM-102 (heptadecan-9-yl 8-{(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino}octanoate), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (PEG2000 DMG). A new study finds some of them, including COVID toes, a measleslike rash and shingles also can be rare, and thankfully brief, side . Moderna COVID-19 Vaccine May Cause Alarming Delayed Side Effect Urticaria was the next most common type of skin reaction associated with the Moderna vaccine. The swelling typically goes down in about two to 11 days. Published 2021. Hyaluronic acid soft tissue filler delayed inflammatory reaction following COVID-19 vaccination - A case report. We declare no competing interests. Moderna COVID-19 Vaccine Information from Drugs.com PMC Get urgent medical attention if you get any of the following signs and symptoms of an allergic reaction: Talk to your doctor or nurse if you develop any other side effects. Shutterstock. The federal government has granted companies. it damages the myelin sheath), Muscle contractions involuntary (uncontrolled muscle contraction), Muscle strain (an injury to a muscle in which the muscle fibres tear), Musculoskeletal chest pain (pain in chest muscle or nerve or bones), Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves), Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves), Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves), Myocarditis (inflammation of heart muscle myocardium), Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels), Nasopharyngitis (inflammation of the nasopharynx), Nausea (feeling of having an urge to vomit), Nervous system disorder (a general class of medical conditions affecting the nervous system), Neurological symptom (symptoms of nervous system disease), Neuropathy peripheral (surface nerve damage), Neutrophil count increased (excess than normal number of neutrophil a type of blood cell), Numbness and tingling (unusual prickling sensations), Ocular discomfort (a generic expression when there is lack of ease in/about the eyes), Ocular hyperaemia (an abnormally large amount of blood in eye), Oral discomfort (pain or irritation in mouth), Oropharyngeal discomfort (pain or irritation of oropharynx), Osteoarthritis (a joint disease caused by cartilage loss in a joint), Paleness (unusual lightness of skin colour), Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect), Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect), Parosmia (distortion of the sense of smell, as in smelling odours that are not present), Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery), Pericardial effusion (fluid around the heart), Pericarditis (inflammation of the pericardium), Pharyngeal hypoaesthesia (pharyngeal -abnormally decreased sensitivity), Photophobia (extreme sensitivity to light), Photopsia (presence of perceived flashes of light), Pneumonia bacterial (pneumonia associated with bacterial infection), Pollakiuria (abnormally frequent passage of relatively small quantities or urine), Polymyalgia rheumatica (pain in many muscles), Postmenopausal haemorrhage (post-menopausal bleeding), Psoriasis (immune-mediated disease that affects the skin), Pulmonary congestion (congestion in the lungs), Pulmonary embolism (blockage of the main artery of the lung), Pulmonary oedema (fluid accumulation in the lungs), Pulmonary thrombosis (scarring in the lungs), Purpura (purplish discoloration of the skin), Rash maculo-papular (red area on the skin that is covered with small confluent bumps), Rash vesicular (rash with a small bubble), Red blood cell sedimentation rate increased, Renal impairment (severely reduced kidney function), Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease), Respiratory disorder (respiratory disease), Respiratory distress (difficulty in breathing), Respiratory rate increased (excess breathing rate/min), Respiratory syncytial virus test negative, Respiratory tract congestion (blockage on respiratory system), Restless leg syndrome (a powerful urge to move your legs), Retching (strong involuntary effort to vomit), Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down), Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints), Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder), Salivary hypersecretion (excess saliva secretion), Scab (a hard coating on the skin formed during the wound healing), Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve), Scleroma (a hardened patch of tissue in the skin or mucous membranes), Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures), Seizures (abnormal excessive or synchronous neuronal activity in the brain), Sepsis (a severe blood infection that can lead to organ failure and death), Septic shock (shock due to blood infection), Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin), Sinus headache (headache caused by sinus infections), Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node), Skin blushing/flushing (a sudden reddening of the face, neck), Skin discoloration - bluish (bluish colour of skin), Skin exfoliation (removal of the oldest dead skin cells), Skin induration (an abnormally hard spot or area on the skin), Speech impairment (adult) (inability to speak (adult)), Stomatitis (inflammation of mucous membrane of mouth), Stroke (sudden death of a portion of the brain cells due to a lack of oxygen), Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle), Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue), Tenderness (pain or discomfort when an affected area is touched), Tendonitis (a condition that causes pain and swelling of tendons), The flu (the flu is caused by an influenza virus), Thrombocytopenia (decrease of platelets in blood), Thrombosis (formation of a blood clot inside a blood vessel), Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)), Tremor (trembling or shaking movements in one or more parts of your body), Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation), Tunnel vision (the loss of peripheral vision with retention of central vision), Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop), Urinary incontinence (inability to control the flow of urine and involuntary urination), Urinary retention (the inability to completely or partially empty the bladder), Urticaria (rash of round, red welts on the skin that itch intensely), Urticaria chronic (long lasting rash of round, red welts on the skin that itch intensely), Vaccination site erythema (redness around vaccination site), Vaccination site lymphadenopathy (abnormal enlargement of the lymph nodes- vaccination site), Vaccination site pruritus (severe itching of the skin at vaccination site), Vasculitis (inflammation of a blood vessel or blood vessels), Ventricular extrasystoles (premature cardiac contraction), Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart), Vitreous floaters (spots before the eyes), Wheezing (a high-pitched whistling sound made while you breath), Simvastatin and Anaemia Of Chronic Disease, Cytarabine and Therapeutic Agent Toxicity, Lansoprazole and Injection Site Urticaria, Staphylococcus Test Positive: 1 person, 50.00%, Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 50.00%, Periorbital Cellulitis (inflammation and infection of the eyelid and the skin surrounding the eye): 1 person, 50.00%, Muscle Aches (muscle pain): 1 person, 50.00%, Culture Wound Positive: 1 person, 50.00%, Cellulitis (infection under the skin): 1 person, 50.00%. Interleukin 1alpha: a comprehensive review on the role of IL-1alpha in the pathogenesis and treatment of autoimmune and inflammatory diseases. Spikevax stimulates the bodys natural defences (immune system). COVID-19 toes, Moderna arm, all-body rash: Vaccines can cause skin lead to localised cellulitis, granuloma formation and abscess. They vary in appearance and size and can sometimes cover most of the upper arm. Spikevax uses a substance called messenger ribonucleic acid (mRNA) to carry instructions that cells in the body can use to make the spike protein that is also on the virus. 2023 eHealthMe.com. The registry showed a total of 10 flares, five after a first dose of Moderna vaccine, one after an initial dose of Pfizer vaccine, and four after the second Pfizer dose. The formulation - officially named Spikevax Bivalent Original/Omicron BA.4-5 (Spikevax Bivalent BA.4/5) - has been given the green light for use in people . While it may cause you discomfort, it's likely not serious and should resolve on its own in a short time (about two to 11 days, according to the NEJM study). Please enter a term before submitting your search. and transmitted securely. COVID-19 Vaccine, mRNA (Moderna) - MedlinePlus This leaflet was last revised December 2022. If You Have a Skin Reaction to the Moderna COVID-19 Vaccine, Don't Panic Moderna to build 150m vaccine centre in UK after NHS deal Administration of Moderna COVID-19 Vaccines | CDC Given the considerable potential for confusion, the researchers called for increased awareness of these skin reactions to help avoid needless diagnostic testing and treatment. An official website of the United States government. Ask your pharmacist how to throw away medicines you no longer use. The phase IV clinical study analyzes which people get Moderna COVID Vaccine and have Cellulitis staphylococcal. Skin reactions can appear days after getting the Moderna COVID-19 vaccine. There are two main COVID-19 vaccines: Pfizer-BioNTech and Moderna. Check with your doctor or nurse immediately if any of the following side effects occur while taking sars-cov-2 (covid-19) mrna-1273 vaccine: More common Chills difficulty in moving fever headache joint pain muscle aches, cramps, pains, or stiffness nausea swollen joints unusual tiredness or weakness vomiting Incidence not known Anxiety According to the report, 472 people died after receiving a Moderna vaccine, while 489 died after receiving a Pfizer vaccine. In order to improve the traceability of biological medicinal products, the name and the batch number of the administered product should be clearly recorded. 2023 Feb 20:1-4. doi: 10.1007/s13691-023-00598-7. Image, Download Hi-res Cutaneous vasculitis following COVID-19 vaccination Some who . They have been observed more often after the second dose compared to the first dose, and more often in younger males. The registry data included a total of eight cases of pernio/chilblains, three each after the first dose of both vaccines and two after the second Pfizer vaccine dose. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. And it started to spread." Eur Rev Med Pharmacol Sci. You can help by reporting any side effects you may get. Moderna COVID-19 vaccine generates long-lasting immune memory "Side effects that have been reported with the Moderna COVID-19 Vaccine include: Injection site reactions: pain, tenderness and swelling of the lymph nodes in the same arm of the injection, swelling (hardness), and redness. They were discussed during the recent AAD virtual meeting and published simultaneously in the Journal of the American Academy of Dermatology. Very large clinical trials have shown that Moderna is effective in preventing COVID-19 in people aged 12 years and older. All patients underwent serologic testing for SARS-CoV-2 infection before vaccination and tested negative, indicating no previous primary infection: hence, vasculitis might have been triggered by maladaptive individual immune responses to a component of the vaccine. UpToDate The mRNA COVID-19 vaccine is a lipid nanoparticle-encapsulated, nucleoside-modified mRNA vaccine that encodes the prefusion spike glycoprotein of the SARS-CoV-2 virus responsible for COVID-19. Clinicians can distinguish SARS-CoV-2 vaccine reactions from cellulitis by the time of onset (approximately a week vs 5 days), by the lack of progression of symptoms, and resolution over 4 to 5 days. Severe cases of COVID arm may be treated with topical steroids. How COVID-19 vaccine works, potential side effects - UC Davis Follow the COVID-19 vaccination schedule (below) based on age and medical condition. Information about storage, expiry, and use and handling are described in the section intended for healthcare professionals in the PDF. PDF Inadvertent subcutaneous injection of COVID-19 vaccine An official website of the United States government. The vaccine works by causing the body to produce protection (antibodies) against the virus that causes COVID-19. government site. If you have previously had episodes of CLS, talk to a doctor before you are given Spikevax. Ten (10) doses (of 0.5mL each) or a maximum of twenty (20) doses (of 0.25mL each) can be withdrawn from each multidose vial. Moderna's Omicron vaccine: When it will be available and who can get it It is vital importance to rein- We therefore aimed to evaluate humoral and cellular immune responses to COVID-19 vaccine BNT162b2 . To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. Most side effects go away within a few days of appearing. Opens in a new tab or window, Visit us on YouTube. by Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis. J Autoimmun. In addition, you can report side effects to ModernaTX, Inc. at 1-866-663-3762. Investigators identified no safety concerns and no evidence of vaccine-associated enhanced respiratory disease (VAERD). Q: Does Moderna COVID-19 Vaccine protect against asymptomatic SARS-CoV-2 infection (i.e., the individual is infected with SARS-CoV-2, but does not have signs or symptoms of COVID-19)? Copyright 2023 Elsevier Inc. except certain content provided by third parties. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. The expiry date refers to the last day of that month. During and after each injection of the vaccine, your doctor, pharmacist or nurse will watch over you Moderna files patent infringement lawsuits against Pfizer and BioNTech Researchers suspect that delayed skin reactions to the Moderna vaccine are caused by an intense reaction by T-cells, a part of the immune system that attacks threats, that occurs at least 12 hours after receiving a dose. A case includes 12 cartons, or a total of 120 vials. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. The phase IV clinical study analyzes which people get Moderna COVID Vaccine and have Cellulitis staphylococcal. Financing covid-19 mRNA vaccines | The BMJ The cells then make antibodies against the spike protein to help fight off the virus. This vaccine contains polyethylene glycol/macrogol (PEG) as part of PEG2000-DMG. sharing sensitive information, make sure youre on a federal National Library of Medicine The delayed skin reactions described in the reports often resembled the raised, red welts that are caused by an insect sting. Not uncommonly, skin reactions were accompanied by systemic effects, including fatigue, myalgia, headache, fever, arthralgia, nausea, and chills. Sixty-year-old woman (patient 1) 24h after initiation of topical steroid treatment; the left arm showed a dramatic decrease in erythema and swelling. This medicine is subject to additional monitoring. -, Belouzard S, Millet JK, Licitra BN, Whittaker GR. All information is observation-only. These reactions, especially if accompanied by systemic symptoms, have been mistaken for cellulitis. MGH: 30 patients develop reaction to Moderna vaccine While unsightly and uncomfortable, the reactions usually resolve within a few days and do not pose any long-term health risks. Meo SA, Bukhari IA, Akram J, Meo AS, Klonoff DC. A shipping pallet may include up to 198 cases. Caroline Tien is a journalist with degrees in English and biology. for at least 15 minutes to monitor for signs of an allergic reaction. Based on the results of skin samples, or biopsies, in both the NEJM and JAMA Dermatology reports the researchers' best guess is that the skin reactions are likely caused by delayed T-cell-mediated hypersensitivityan intense immune response that begins a minimum of 12 hours after contact with a pathogen or allergen, meaning an infectious or irritating substance. Moderna's coronavirus vaccine may cause alarming delayed side effects from its first dose among a portion of recipients. FOIA General side effects: fatigue, headache, muscle pain, joint pain, chills, nausea and vomiting, and fever. Unable to load your collection due to an error, Unable to load your delegates due to an error. Polyethylene glycol (PEG) 2000 dimyristoyl glycerol (DMG) 1,2-distearoyl-sn-glycero-3-phosphocholine; Cholesterol; SM-102 (Proprietary to Moderna) Salts. Among those who received the Moderna vaccine, delayed large local skin reactions were most common, occurring in 175 of 267 (66%) patients after the first dose and 31 of 102 (30%) after the. Who can get a COVID-19 vaccine Everyone aged 5 (on or before 31 August 2022) and over can get a 1st and 2nd dose of the COVID-19 vaccine. Respiratory symptoms, including nasal discharge, nasal congestion, change in voice quality, stridor, cough, wheeze, and dyspnea. Before Prepare and administer the vaccine following manufacturer's guidance which is outlined in CDC's Preparation and Administration summary below. QJM. Getting COVID-19 can cause all manner of odd skin reactions. By contrast, 244 (0.8%) developed a delayed skin reactiondefined as a skin reaction that appears eight or more days laterafter getting their first dose, and 68 (0.2%) developed a delayed skin reaction after getting their second dose. Authors Sathishkumar Ramalingam 1 , Harkesh Arora 2 , Susan Lewis 2 , Kulothungan Gunasekaran 3 , Maheswari Muruganandam 4 , Sivakumar Nagaraju 2 , Priyesh Padmanabhan 5 Affiliations Measles-like morbilliform rash occurred after the first dose of Moderna vaccine in 4.1% of patients and after the second dose in 6.9%. Moderna COVID-19 vaccine for children aged 6 months to 5 years: information for parents and guardians - 09092022 - Lao. Moderna's Covid-19 vaccine can cause skin reactions 11 DAYS after jab News. 8600 Rockville Pike The doses are administered 28 days apart, and the vaccine trains the immune system to fight against future. COVID-19 vaccine benefits What are the benefits of getting a COVID-19 vaccine? Federal government websites often end in .gov or .mil. Spikevax can be given during breastfeeding. COVID-19 vaccines protect against the SARS-CoV-2 virus only, so it's still important to keep yourself healthy and well. The Moderna COVID-19 Vaccine includes the following ingredients: Active ingredient. Different individuals may respond to medication in different ways. A new COVID-19 vaccine from Moderna targeting Omicron variants BA.4 and BA.5 will land in April. The third dose may still COVID Arm: Delayed Hypersensitivity Reactions to SARS-CoV-2 Vaccines Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection) is found to be associated with 555 drugs and 257 conditions by eHealthMe. * Approximation only. 2022 Nov;77(11):3426-3434. doi: 10.1111/all.15414. While information on effects on pregnancy or the newborn baby after vaccination during the first trimester is limited, no change to the risk for miscarriage has been seen. Spikevax is is a white to off white dispersion supplied in a glass vial with a rubber stopper and aluminium seal. "People were confusing these delayed reactions with cellulitis or skin infection, and so we were able to provide reassurance," said Freeman. This is not a complete list of side effects and others may occur. COVID-19 vaccine efficacy and effectiveness-the elephant (not) in the room. Access the latest 2019 novel coronavirus disease (COVID-19) content from across The Lancet journals as it is published. DOI: https://doi.org/10.1016/S2665-9913(21)00309-X. Opens in a new tab or window, Visit us on TikTok. If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. COVID-19 mRNA Vaccine (nucleoside modified). Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. Thromethamine Australian health minister Greg Hunt in hospital with infection cellulitis after Covid vaccine | Daily Mail Online Grim details of Health Minister Greg Hunt's serious infection are. Management of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivity. Less commonly, patients had episodes of zoster (shingles), herpes simplex flares, and rosacea-like reactions. Symptoms of COVID arm include: itching, which can be intense a red or discolored rash that varies in size from quarter-sized to very large in some instances, the rash may spread to your hands or. They give you the best protection against COVID-19. If you have any further questions on the use of this vaccine, ask your doctor, pharmacist or nurse. Cellulitis staphylococcal in Pfizer BioNTech COVID Vaccine, Cellulitis staphylococcal in Johnson & Johnson COVID Vaccine, Abortion spontaneous (naturally occurring miscarriage), Acute myocardial infarction (acute heart attack), Ageusia (loss of taste functions of the tongue), Agitation (state of anxiety or nervous excitement), Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death), Angioedema (rapid swelling of the dermis), Appendicitis (inflammation of the appendix), Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat), Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires), Arthritis (form of joint disorder that involves inflammation of one or more joints), Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem), Atelectasis (partial or complete collapse of the lung), Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles), Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue), Belching (release of gas from the digestive tract), Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure), Blood thyroid stimulating hormone decreased, Bradycardia (abnormally slow heart action), Breast lump (localized swelling that feels different from the surrounding breast tissue), Bronchitis (inflammation of the mucous membrane in the bronchial tubes), Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder), Canker sores (painful, open sore in the mouth), Cardiomyopathy (weakening of the heart muscle), Cardio-respiratory arrest (sudden dysfunction of heart and lungs), Cerebral haemorrhage (bleeding within the brain), Cerebral infarction (less blood supply to brain resulting tissue damage), Chapped lips (cracking, fissuring, and peeling of the skin f lip), Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe), Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving), Concussion (short loss of normal brain function in response to a head injury), Coronary heart disease (narrowing or blockage of the coronary arteries), Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis), Dehydration (dryness resulting from the removal of water), Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it), Dermatitis allergic (inflammation of the skin due allergic reaction), Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens), Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall), Dyskinesia (abnormality or impairment of voluntary movement), Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear), Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters), Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat), Ejection fraction decreased (systolic heart failure), Encephalopathy (functioning of the brain is affected by some agent or condition), Erythema multiforme (a type of hypersensitivity reaction), Euphoric mood (excessively happy but may become angry or irritable), Eyelid ptosis (falling of the upper or lower eyelid), Eyelid twitch (spontaneous and uncontrolled spasms of the muscles), Facial paralysis (loss of function of face muscle), Facial paresis (weakness in facial muscle movement), Fainting (loss of consciousness and postural tone), Feeding disorder (when children refuse to eat certain food groups), Fibromyalgia (a long-term condition which causes pain all over the body), Flank pain (a distressing sensation experienced around the lower back and the upper abdomen), Flatulence (flatus expelled through the anus), Fluid retention (an abnormal accumulation of fluid in the blood), Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin), Gallstones (stone formation by bile component), Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus), Gastrointestinal disorder (functional problems of gastrointestinal tract), Gastrointestinal haemorrhage (bleeding gastrointestinal tract), General physical health deterioration (weak health status), Glossodynia (a burning or painful sensation in the tongue), Gout (uric acid crystals building up in the body), Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system), Haematochezia (passage of stools containing blood), Haematoma (collection of blood outside the blood vessels), Hallucinations (sensations that appear real but are created by your mind), Heart palpitations (feelings or sensations that your heart is pounding or racing), Hemiparesis (weakness on one side of the body), Hemiplegia (paralysis of one side of the body), Herpes simplex (herpes simplex is a common viral infection), Hyperacusis (disorder in loudness perception), Hyperhidrosis (abnormally increased sweating), Hyperkalemia (damage to or disease of the kidney), Hypoaesthesia (reduced sense of touch or sensation), Hypoaesthesia oral (reduced sense of touch or sensation in mouth), Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration), Hypotension (abnormally low blood pressure), Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development), Idiopathic or primary livedo reticularis (netlike pattern of reddish-blue skin discoloration, usually on the legs), Incoherent (talking in a confused and unclear way), Incontinence (lack of moderation or self-control), Injection site cellulitis (injection site inflammation), Injection site erythema (redness at injection site), Injection site haemorrhage (bleeding from injection site), Injection site nodule (small swelling or aggregation of cells in the body, esp.